2021 International Conference on Biomedical and Bioinformatics Engineering (ICBBE 2021)
Prof. Ahmed EI-Hashash

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Speech title:

Stem cells in lung repair, regeneration, and diseases: Current applications and future promise

Abstract:

Tissue engineering and cellular therapies have a remarkable potential to significantly impact  medicine/biomedicine. Lung diseases are major cause of morbidity and mortality worldwide. The  progress in regenerative medicine and stem cell research in the lung are currently a fast‐growing  research topic that can provide solutions to these major health problems. Under normal conditions,  the rate of cellular proliferation is relatively low in the lung in vivo, compared to other major organ  systems. Lung injury leads to the activation of stem/progenitor cell populations that re‐enter the cell  cycle. Yet, little is known about stem cells in the lung, despite common thoughts that these cells  could play a critical role in the repair of lung injuries. Nor do we fully understand the cellular and  architectural complexity of the respiratory tract, and the diverse stem/progenitor cells that are  involved in the lung repair and regeneration. In this talk, we will present and discuss the conceptual  framework of lung stem/progenitor cell biology. We will also describe our research studies and  related research by others on some lung diseases, in which stem cell manipulations may be  physiologically significant. Furthermore, we highlight the challenges of lung stem cell‐based therapy.